<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ji, Ping</style></author><author><style face="normal" font="default" size="100%">Diederichs, Sven</style></author><author><style face="normal" font="default" size="100%">Wang, Wenbing</style></author><author><style face="normal" font="default" size="100%">Böing, Sebastian</style></author><author><style face="normal" font="default" size="100%">Metzger, Ralf</style></author><author><style face="normal" font="default" size="100%">Schneider, Paul M.</style></author><author><style face="normal" font="default" size="100%">Tidow, Nicola</style></author><author><style face="normal" font="default" size="100%">Brandt, Burkhard</style></author><author><style face="normal" font="default" size="100%">Buerger, Horst</style></author><author><style face="normal" font="default" size="100%">Bulk, Etmar</style></author><author><style face="normal" font="default" size="100%">Michael Thomas</style></author><author><style face="normal" font="default" size="100%">Wolfgang E. Berdel</style></author><author><style face="normal" font="default" size="100%">Hubert Serve</style></author><author><style face="normal" font="default" size="100%">Carsten Müller-Tidow</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">MALAT-1, a Novel Noncoding RNA, and Thymosin β4 Predict Metastasis and Survival in Early-Stage Non-Small Cell Lung Cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Oncogene</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2003</style></year></dates><volume><style face="normal" font="default" size="100%">22</style></volume><pages><style face="normal" font="default" size="100%">8031-8041</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Early-stage non-small cell lung cancer (NSCLC) can be cured by surgical resection, but a substantial fraction of patients ultimately dies due to distant metastasis. In this study, we used subtractive hybridization to identify gene expression differences in stage I NSCLC tumors that either did or did not metastasize in the course of disease. Individual clones (n 1&amp;frasl;4 225) were sequenced and quantitative RT&amp;ndash;PCR verified overexpression in metastasizing samples. Several of the identified genes (eIF4A1, thymosin b4 and a novel transcript named MALAT-1) were demonstrated to be significantly associated with metastasis in NSCLC patients (n 1&amp;frasl;4 70). The genes&amp;rsquo; association with metastasis was stage- and histology specific. The Kaplan&amp;ndash;Meier analyses identified MALAT-1 and thymosin b4 as prognostic parameters for patient survival in stage I NSCLC. The novel MALAT-1 transcript is a noncoding RNA of more than 8000nt expressed from chromosome 11q13. It is highly expressed in lung, pancreas and other healthy organs as well as in NSCLC. MALAT-1 expressed sequences are conserved across several species indicating its potentially important function. Taken together, these data contribute to the identification of early-stage NSCLC patients that are at high risk to develop metastasis. The identification of MALAT-1 emphasizes the potential role of noncoding RNAs in human cancer.&lt;/p&gt;
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